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Regulatory mechanism of bombesin on gastrin release
Author(s) -
AZUMA TAKESHI,
INOKUCHI HIDETO,
KAWAI KEIICHI
Publication year - 1988
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1988.tb00259.x
Subject(s) - bombesin , gastrin , antrum , medicine , endocrinology , vagotomy , g cell , atropine , endogeny , stimulation , stomach , neuropeptide , secretion , receptor
Bombesin has been demonstrated to stimulate gastrin release by an atropine‐resistant mechanism. In the present study, the effects of truncal vagotomy and chemical sympathectomy on the gastrin release by exogenous and endogenous bombesin using rat antral mucosa in tissue culture were studied. Exogenous bombesin 10 ‐8 mol/l significantly stimulated gastrin release. The stimulation of gastrin release by bombesin was abolished by truncal vagotomy, but not altered by chemical sympathectomy. Bombesin antiserum inhibited gastrin release by blocking the effect of endogenous bombesin. The inhibition of gastrin release by bombesin antiserum was abolished by truncal vagotomy, but not altered by chemical sympathectomy. In addition, the concentrations of bombesin‐like immunoreactivity in antral mucosa were not altered by truncal vagotomy. These results suggest that the mechanism of gastrin release by bombesin is influenced by non‐cholinergic local nerves under vagal control.