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Diurnal variations in serum levels, urinary excretion and renal clearances of pepsinogen A and C *
Author(s) -
KATE R.W. TEN,
PALS G.,
DONKER A.J.M.,
ERIKSSON A.W.,
MEUWISSEN S.G.M.
Publication year - 1988
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1988.tb00255.x
Subject(s) - pepsin , medicine , excretion , endocrinology , urinary system , kidney , creatinine , biology , biochemistry , enzyme
Diurnal variations in serum levels, urinary excretion and renal clearances of pepsinogen A and pepsinogen C were investigated in eight healthy volunteers during a consecutive 63‐h observation period. Both serum pepsinogen A and pepsinogen C levels proved to be stable and unaffected by meals. Urinary excretion of pepsinogen A, and thus pepsinogen A clearance by the kidney, increased during the day. These changes might be related to food intake. Pepsinogen C and creatinine excretion were constant throughout the day as were the renal clearances of these substances. It is concluded that the kidney plays an important role in maintaining stable serum pepsinogen A levels despite changes in release of pepsinogen A into the circulation during the day. Changes in urinary excretion of pepsinogen A might reflect more accurately short‐term changes in gastric secretory activity than do serum levels. The handling of pepsinogen C by the kidney needs further investigation.