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Effect of cholestasis produced by temporary bile‐duct occlusion on hepatic glutathione and γ‐glutamyl transferase levels in the pig
Author(s) -
SHI E. C. P.,
ROSE M. A.,
HAM J. M.
Publication year - 1988
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1988.tb00228.x
Subject(s) - glutathione , cholestasis , detoxification (alternative medicine) , metabolite , medicine , bile duct , endocrinology , drug metabolism , biotransformation , glutathione s transferase , pharmacology , biochemistry , metabolism , biology , pathology , enzyme , alternative medicine
Important factors in drug metabolite‐induced hepatocellular injury are the production of toxic intermediaries by biotransformation processes and the protective capacity of hepatic detoxification systems. In the present study, the hepatic total glutathione (reduced glutathione plus oxidized glutathione), and γ‐glutamyl transferase (γGT) levels, which are important components of a hepatic detoxification system, were measured in pigs before, during, and after bile‐duct occlusion (BDO). The hepatic reduced glutathione (GSH) level fell significantly in the group with BDO compared with a sham operated control group. However, there were no significant changes in the hepatic oxidized glutathione (GSSG) and γGT levels in the two groups. It was also demonstrated that the hepatic GSH level returned to normal 1 week after the BDO was relieved.