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Aqueous or emulsified diazepam in upper endoscopy: A randomized trial
Author(s) -
CHUNG S.C.S.,
LEUNG J.W.C.
Publication year - 1988
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1988.tb00227.x
Subject(s) - diazepam , medicine , endoscopy , thrombophlebitis , anesthesia , randomized controlled trial , sedative , complication , venous thrombosis , surgery , thrombosis
A randomized comparison between diazepam in aqueous form and in fatty emulsion was performed in Chinese patients undergoing upper gastrointestinal endoscopy. One hundred and eighty‐four patients completed the study. The sedative effect is similar with both preparations. Aqueous diazepam caused significantly more pain on injection (75%) and more late venous complication (41%) than the emulsified form (13% and 9% respectively). Thrombosis and thrombophlebitis frequently extended beyond the site of injection. Diazepam in emulsion form caused significantly less venous complications and is therefore superior to the aqueous form for intravenous use.