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Prophylaxis against ERCP sepsis with cefoperazone
Author(s) -
PATTINSON NEIL R.,
CHAPMAN BRUCE A.
Publication year - 1987
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1987.tb00204.x
Subject(s) - medicine , cefoperazone , endoscopic retrograde cholangiopancreatography , cholestasis , cannula , gastroenterology , common bile duct , bile duct , surgery , antibiotics , pancreatitis , microbiology and biotechnology , imipenem , antibiotic resistance , biology
Fifty patients were given cefoperazone (1 g) intravenously over 2–3 min immediately prior to endoscopic retrograde cholangiopancreatography (ERCP). In 16 of these subjects an aliquot of common duct bile was obtained via the ERCP cannula at the commencement of the procedure. Therapeutic biliary levels of cefoperazone were found in 10 subjects. Cholestasis and sampling distal to calculi may account for those in whom undetectable levels were found. Multiple samples from one patient showed that the biliary concentration increased with time. Therapeutic serum levels were detected in all patients and no side effects were observed.