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Response of the gastric mucosa to manipulation of gastric acid output in the cervical cord transected rat
Author(s) -
MACLELLAN DONALD G.,
SHULKES ARTHUR,
HARDY KENNETH J.
Publication year - 1987
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1987.tb00166.x
Subject(s) - cimetidine , pentagastrin , medicine , gastric mucosa , gastric acid , saline , spinal cord , anesthesia , stomach , gastroenterology , endocrinology , psychiatry
The role played by gastric acid in stress ulceration following acute quadriplegic injury was examined in the C7 cord transected rat. Gastric acid output was manipulated by intraperitoneal administration of cimetidine (50 mg/kg), pentagastrin (5μg/kg) or saline in equal volumes. In comparison with control values (78 μEq/h per 200 g rat weight), cimetidine significantly decreased (16 μEq/h per 200 g) and pentagastrin increased (156 μEq/h per 200 g) the median gastric acid output. However, while cimetidine also significantly reduced the resultant ulceration, pentagastrin did not significantly enhance the ulceration compared with the control values. Furthermore, there was no correlation between gastric acid output and total ulcer length in any of the groups. It is concluded that while acid plays a permissive role in ulcerogenesis, factors other than acid define the quantity of gastric stress ulceration following acute spinal injury.