Premium
Failure of autologous mixed lymphocyte reaction in patients with auto‐immune chronic active hepatitis
Author(s) -
KURIHARA TAKESHI,
YAMAUCHI KATSUMI,
NAKANISHI TOSHIMI,
OBATA HIROSHI
Publication year - 1987
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1987.tb00145.x
Subject(s) - mixed lymphocyte reaction , medicine , peripheral blood mononuclear cell , immune system , lymphocyte , immunology , chronic hepatitis , hepatitis , t lymphocyte , antigen , t cell , in vitro , virus , biology , biochemistry
T cells are effectively stimulated by DR ‐antigens on the surface of autologous non‐T cells. This phenomenon, referred to as an autologous mixed lymphocyte reaction (AMLR), is reported to be impaired in several auto‐immune diseases. In the present study, both AMLR and allogeneic mixed lymphocyte reaction (allo‐MLR) activities of peripheral blood mononuclear cells were examined from patients with auto‐immune chronic active hepatitis. AMLR activity in these patients was much lower than that of controls, while allo‐MLR activity of the same patients revealed no abnormality with regard to either stimulator or responder activities in comparison to controls. Furthermore, co‐culture experiments using cells from patients and their HLA‐identical siblings suggested that the defect resided in the responder T cells rather than in the stimulator non‐T cells.