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Gut immunity to typhoid: The immune response to a live oral typhoid vaccine Ty21a
Author(s) -
BARTHOLOMEUSZ R. C. A.,
LABROOY J. T.,
JOHNSON M.,
SHEARMAN D. J. C.,
ROWLEY D.
Publication year - 1986
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1986.tb01757.x
Subject(s) - typhoid fever , typhoid vaccine , medicine , antibody response , immune system , immunology , immunity , vaccination , virology
The oral typhoid vaccine, Ty21a, generated an intestinal antibody response that was consistent and long‐lasting in contrast to the irregular response it generated in serum. Studies with different doses of the vaccine showed that 10 9 organisms appeared to be around the threshold dose required for a response and there was an increase in the consistency and magnitude of the response without side effects up to the maximum dose used of 10 11 organisms. Revaccination after 6 months generated a further response though this response did not have the features of a memory response.