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Portal circulation before and after sclerotherapy for oesophageal varices studied by radionuclide angiography
Author(s) -
SHIOMI SUSUMU,
IKEOKA NAOKO,
KUROKI TETSUO,
HARIHARA SHIGEYOSHI,
KAMATA TEISUKE,
KOBAYASHI KENZO,
YAMAMOTO SUKEO,
MONNA TAKEYUKI,
OCHI HIRONOBU
Publication year - 1986
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1986.tb00779.x
Subject(s) - medicine , cirrhosis , esophageal varices , sclerotherapy , radionuclide angiography , portal hypertension , varices , gastroenterology , angiography , portal venous pressure , radiology , heart failure , ejection fraction
Radionuclide angiography was used to generate curves of first‐pass radioactivity vs. time for the right hepatic lobe and both kidneys following the rapid intravenous injection of 10 mCi of 99m Tc‐phytate. By analysis of the right hepatic curve, the arterial and portal components of the liver circulation were calculated in 21 healthy subjects and 183 patients, 39 with chronic hepatitis and 144 with cirrhosis of the liver. ABSTRACT In the healthy subjects, the portal component (PC) of liver blood supply ranged from 64% to 79% (mean 71.5%). In patients with hepatitis the mean PC was 61.3%, and in patients with cirrhosis it was 37.9%. The PC was lower in cirrhotic patients with oesophageal varices than in those without ( P < 0.001). ABSTRACT The PC was assessed in 23 of the patients with cirrhosis before and after sclerotherapy for oesophageal varices. A paired t ‐test showed significant rises in this component immediately after the final treatment ( P < 0.001). Two months after this treatment, the mean PC had dropped significantly, approaching the pre‐treatment value ( P < 0.001). One year after treatment, the PC had not dropped further. ABSTRACT These findings suggest that this non‐invasive method may be useful for the assessment of portal circulatory changes in cirrhosis, and of results of sclerotherapy for oesophageal varices.