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Effect of diisopropyl 1,3‐dithiol‐2‐ylidinemalonate on rat liver and AFP‐positive cells in 3′‐Me‐DAB hepatocarcinogenesis
Author(s) -
TAKINO TATSURO,
IWAI MASAKI,
OKUNO TADAO,
ISHII MASARU,
KOMATSU MASAMI,
SUGIMOTO TATSUYOSHI
Publication year - 1986
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1986.tb00778.x
Subject(s) - medicine , pathology , hepatocellular carcinoma , cancer research , microbiology and biotechnology , biology
The simultaneous administration of diisopropyl, 1,3‐dithiol‐2‐ylidinemalonate (malotilate) suppressed the proliferation of AFP‐positive oval cells, the formation of hyperplastic nodules and the appearance of clusters of AFP‐positive cells in rat liver with hyperplastic nodules in 3′‐methyl‐4‐dimethylaminoazobenzene (3′‐Me‐DAB) hepatocarcinogenesis. The development of hepatocarcinoma, induced by 3′‐Me‐DAB, was delayed in rats treated with malotilate; therefore, the simultaneous administration of malotilate worked as an inhibitory effect on 3′‐Me‐DAB hepatocarcinogenesis.