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The effect of omeprazole on 24 h intragastric pH and fasting plasma gastrin during low dosage (10 mg) in the morning or the evening
Author(s) -
PRICHARD P. J.,
YEOMANS N. D.,
SHULKES A.,
JONES D. B.,
BUCKLE P. J.,
SMALLWOOD R. A.,
LOUIS W. J.
Publication year - 1986
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1986.tb00125.x
Subject(s) - omeprazole , morning , evening , medicine , dose , gastrin , endocrinology , plasma concentration , physics , astronomy , secretion
The effect of a low dose of omeprazole on intragastric acidity and fasting plasma gastrin concentration was measured in eight subjects with duodenal ulcer in remission. Intragastric acidity was measured during a baseline 24 h period. This was then repeated after 14 days of dosage with 10 mg of omeprazole administered daily, either in the morning or the evening, using a randomized, double‐blind cross‐over design. The median 24 h pH level rose significantly from a baseline of 1.6, to 3.1 and 3.5 during morning and evening dosages, respectively. However, variability in the response to this dose was substantial: three subjects exhibited no discernible change in 24 h median acidity on two occasions, while in others it was reduced by greater than 99%. Fasting plasma gastrin concentrations were not significantly altered by the administration of 10 mg of omeprazole daily for 2 weeks.