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Sphincter of Oddi motor activity in patients with stones in gall‐bladder, common bile duct or intrahepatic duct and the effect of morphine
Author(s) -
MATSUMOTO SHINJI,
TANAKA MASAO,
IKEDA SEIYO,
YOSHIMOTO HIDEO,
NAKAYAMA FUMIO,
Matsumoto S.,
Tanaka M.,
Ikeda S.,
Yoshimoto H.,
Nakayama F.
Publication year - 1986
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.1986.tb00116.x
Subject(s) - sphincter of oddi , medicine , common bile duct , gastroenterology , sphincter , morphine , bile duct , basal (medicine) , surgery , insulin
Sphincter of Oddi phasic motor activity and common bile duct pressure were investigated in controls (seven patients) and in patients with gall‐bladder stones (five patients), common bile duct stones (15 patients), or intrahepatic stones (13 patients). There were no significant differences in amplitude and frequency of the phasic activity or the common bile duct pressure between the controls and disease groups. Basal pressure of the phasic contraction, however, was significantly lower in patients with common bile duct or intrahepatic stones than in the controls or gall‐bladder stone group. The administration of morphine, known to cause spasm of the sphincter of Oddi, increased the basal pressure and frequency of the phasic waves in all groups, while the amplitude remained unchanged. Response to morphine in patients with common bile duct or intrahepatic stones was similar to the controls. However, the basal pressure in these latter groups was lower than in the controls, even after stimulation by morphine. The high incidence of bacterial growth in bile from these patients hitherto reported may be attributable to ascending infection possibly resulting from the low basal pressure of the sphincter of Oddi.