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Guarding the immune system: Suppression of autoimmunity by CD4 + CD25 + immunoregulatory T cells
Author(s) -
Zwar Tricia D,
Van Driel Ian R,
Gleeson Paul A
Publication year - 2006
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/j.1440-1711.2006.01471.x
Subject(s) - il 2 receptor , foxp3 , immune system , immunology , autoimmunity , biology , regulatory t cell , immune tolerance , population , microbiology and biotechnology , autoimmune disease , interleukin 21 , peripheral tolerance , t cell , medicine , antibody , environmental health
CD4 + CD25 + Foxp3 + T cells (CD25 + T regulatory [Treg] cells) are a naturally occurring suppressor T‐cell population that regulates a wide variety of immune responses. A major function of CD25 + Treg cells is to inhibit the activity of self‐reactive T cells that can potentially cause autoimmune disease. This review examines the recent advances in CD25 + Treg cell biology, with particular focus on the thymic and peripheral development of CD25 + Treg cells, the signals that promote their expansion and maintenance in the periphery and the mechanism by which they mediate their suppressor activity in peripheral lymphoid tissues. An understanding of these issues is likely to facilitate the development of CD25 + Treg‐cell‐based therapies for the treatment of autoimmune disease.