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Reserpine‐induced model of stress suppresses mucosal immunity
Author(s) -
Bao Shisan,
Fei Jian,
Shen Jie,
Gong Sheng J,
Fang Huang,
Husband Alan J
Publication year - 2006
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/j.1440-1711.2006.01468.x
Subject(s) - reserpine , immunity , stress (linguistics) , mucosal immunity , medicine , pharmacology , immunology , immune system , linguistics , philosophy
Stress contributes significantly to the development of many diseases. In clinical studies, a strong correlation between depression and immune dysfunction has been shown. Our previous studies indicated that sympathetic innervation can regulate intestinal mucosal immunity through sympathetic synapses, but the mechanism in stress/depression‐induced intestinal immune deficiency was unclear. Using a mouse model in which behavioural stress/depression is chemically induced by reserpine, it is found that there is a substantial deficiency of intestinal local humoral and particularly specific antibody response to the antigen stimulation in reserpine‐treated group. No significant difference of CD4 + , CD8 + or Mac1 + cells between reserpine‐treated and control groups was detected in the intestine. This deficiency is closely correlated with stress/depression. A possible correlation between stress, cytokine secretion and humoral immunity in vivo is postulated.