Premium
Cell surface markers of regulatory T cells are not associated with increased forkhead box p3 expression in blood CD4 + T cells from HIV‐infected patients responding to antiretroviral therapy
Author(s) -
Lim Andrew YF,
Price Patricia,
Beilharz Manfred W,
French Martyn A
Publication year - 2006
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/j.1440-1711.2006.01467.x
Subject(s) - foxp3 , immunology , biology , il 2 receptor , cd8 , immune system , cell , t cell , regulatory t cell , virology , genetics
Regulatory T (Treg) cells may attenuate host immune responses to pathogens, including HIV and opportunistic pathogens in HIV‐infected patients. Treated and untreated progressive HIV disease represent a range of immunological scenarios with potentially different roles for Treg cells. A cell surface marker to determine Treg cell numbers would assist in identifying situations where Treg cells are important. Here we show that levels of Foxp3 mRNA are increased in CD4 + T cells from HIV‐infected patients responding to antiretroviral therapy. However, the proportion of peripheral blood CD4 + and CD8 + T cells expressing CD25, neuropilin‐1, glucocorticoid‐induced TNF receptor and lymphocyte activation gene‐3 did not differ as a result of treated or untreated HIV infection when compared with HIV‐seronegative controls. Hence, none of the putative Treg cell surface markers identified T‐cell populations in peripheral blood that mirrored the effects of HIV infection and antiretroviral therapy on Foxp3 expression.