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Role of Bid‐induced mitochondrial outer membrane permeabilization in granzyme B‐induced apoptosis
Author(s) -
Waterhouse Nigel J,
Sedelies Karin A,
Trapani Joseph A
Publication year - 2006
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/j.1440-1711.2005.01416.x
Subject(s) - granzyme , granzyme b , programmed cell death , cytotoxic t cell , apoptosis , granzyme a , microbiology and biotechnology , biology , chemistry , perforin , biochemistry , in vitro
Cytotoxic lymphocytes (CL) induce death of their targets by granule exocytosis. During this process, enzymes contained within cytotoxic granules (granzymes) are delivered to the target cell where the enzymes trigger the cell death by cleaving specific substrates. Granzyme B is the only granzyme that has been shown to induce cell death by apoptosis, but the exact pathway by which this is achieved has been the subject of hot debate. Furthermore, several other death‐inducing granzymes have been identified; therefore, the exact contribution of granzyme B to CL‐induced death is unclear. In this study, we discuss our recent findings on granzyme B‐induced cell death and discuss the potential relevance of this pathway to CL‐induced death of viral‐infected and transformed cells.