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Compartmentalization in T‐cell signalling: Membrane microdomains and polarity orchestrate signalling and morphology
Author(s) -
Russell Sarah,
Oliaro Jane
Publication year - 2006
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/j.1440-1711.2005.01415.x
Subject(s) - compartmentalization (fire protection) , signalling , microbiology and biotechnology , lipid raft , biology , cell signaling , extracellular , juxtacrine signalling , lipid microdomain , signal transduction , cell , receptor , neuroscience , membrane , biochemistry , paracrine signalling , enzyme
Lymphocyte function is regulated by complex signalling responses to diverse extracellular inputs, and a cell will often receive multiple, conflicting signals at one time. The mechanisms by which a lymphocyte integrates these signals into a single cellular response are not well understood. An important factor in the integration of signals likely involves the regulation of access of signalling molecules to cell surface receptors and of receptor signals to morphological determinants within the cell. Recent studies have led to important advances in our understanding of both the mechanisms by which signals are compartmentalized in T cells and the physiological role played by such compartmentalization. We review progress in the field, with a particular focus on membrane microdomains or lipid rafts and on cell polarity.