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Blood brothers: Carbohydrates in xenotransplantation and cancer immunotherapy
Author(s) -
Ramsland Paul A
Publication year - 2005
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/j.1440-1711.2005.01367.x
Subject(s) - xenotransplantation , glycobiology , immunotherapy , cancer , cancer immunotherapy , immunology , biology , medicine , immune system , glycoprotein , transplantation , genetics , glycan
Carbohydrate antigens have a central role in the hyperacute rejection of animal‐to‐human organ grafts (xenotransplantation) and they are emerging in importance in the immunotherapy of cancer. This article traces the historical origins of the discovery of key carbohydrate antigens and explores the future impact of recent technological advances of the field of glycobiology as it relates to xenotransplantation and cancer.