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Multipotential acceptance of Peyer's patches in the intestine for both thymus‐derived T cells and extrathymic T cells in mice
Author(s) -
Takahashi Satoshi,
Kawamura Toshihiko,
Kanda Yasuhiro,
Taniguchi Tomoyo,
Nishizawa Tetsuro,
Iiai Tsuneo,
Hatakeyama Katsuyoshi,
Abo Toru
Publication year - 2005
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/j.1440-1711.2005.01361.x
Subject(s) - intraepithelial lymphocyte , peyer's patch , biology , t cell , immunology , cd8 , small intestine , mesenteric lymph nodes , cd3 , cd5 , microfold cell , immune system , microbiology and biotechnology , cytotoxic t cell , antigen , endocrinology , in vitro , biochemistry
Peyer's patches (PP) are important inductive sites for the mucosal immune response. It is well known that lymphocytes that migrate into PP are mainly of T‐cell lineage from thymus‐derived cells (i.e. αβTCR high cells). In this study, we further characterized the properties of PP lymphocytes in mice using a mouse model of colitis induced by dextran sulphate sodium (DSS). Although the major site of the inflammation induced by DSS is known to be the large intestine, the small intestine was also damaged. When mice developed DSS‐induced colitis, CD3 + CD8 + B220 + γδ T cells increased in PP in the small intestine. These γδ T cells, which are not seen in the PP of normal mice, resembled intraepithelial lymphocytes (IEL) in the small intestine in terms of their expression of CD5, CD103 and Thy1.2. In addition, the Vγ/δ repertoire of these γδ T cells was similar to that of γδ IEL. When DSS‐treated mice were injected with IEL isolated from normal mice, IEL including γδ T cells preferentially migrated to PP, raising the possibility that B220 + T cells seen in PP of diseased mice may derive from IEL in the small intestine. Our present study suggests that PP might be able to accept T‐cell lineages from intestinal IEL as well as from thymus‐derived T cells.