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Cytokines as adjuvants for avian vaccines
Author(s) -
Asif Manija,
Jenkins Kristie A,
Hilton Louise S,
Kimpton Wayne G,
Bean Andrew GD,
Lowenthal John W
Publication year - 2004
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/j.1440-1711.2004.01295.x
Subject(s) - vaccination , adjuvant , immune system , immunology , vaccine adjuvant , medicine , microbiology and biotechnology , biology
The worldwide trend towards a reduced reliance on in‐feed antibiotics has increased the pressure to develop alternative strategies to manage infectious diseases in poultry. With this in mind, there is a great emphasis on vaccine use and the enhancement of existing vaccines to provide long‐term protection. Currently existing adjuvants for poultry can have deleterious side‐effects, such as inflammation, resulting in the down‐grading of meat quality and a subsequent reduction in profits. Therefore, to enhance the use of vaccination, alternative adjuvants must be developed. The use of recombinant cytokines as adjuvants in poultry is attracting considerable attention, and their potential role as such has been addressed by several studies. The recent identification of a number of chicken cytokine genes has provided the possibility to study their effectiveness in enhancing the immune response during infection and vaccination. This review focuses on the recent studies involving the assessment of cytokines as vaccine adjuvants.