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Exercise and cytokines
Author(s) -
Pedersen Bente Klarlund
Publication year - 2000
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1111/j.1440-1711.2000.t01-11-.x
Subject(s) - cytokine , chemokine , endocrinology , medicine , physical exercise , receptor , inflammation , tumor necrosis factor alpha , skeletal muscle , exercise intensity , interleukin , immunology , heart rate , blood pressure
Strenuous exercise induces increased levels in a number of pro‐inflammatory and anti‐inflammatory cytokines, naturally occurring cytokine inhibitors and chemokines. Thus, increased plasma levels of TNF‐α, IL‐1, IL‐6, IL‐1receptor antagonist, TNF receptors, IL‐10, IL‐8 and macrophage inflammatory protein‐1 are found after strenuous exercise. The concentration of IL‐6 increases up to 100‐fold after a marathon race. The increase in IL‐6 is tightly related to the duration of the exercise and there appears to be a logarithmic relationship. Furthermore, the increase in IL‐6 is related to the intensity of exercise. Given the facts that IL‐6, more than any other cytokine, is produced in large amounts in response to exercise, that IL‐6 is produced locally in the skeletal muscle in response to exercise and that IL‐6 is known to have growth factor abilities, it is likely that IL‐6 plays a beneficial role and may be involved in mediating exercise‐related metabolic changes.