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STAT signaling in Dictyostelium development
Author(s) -
Kawata Takefumi
Publication year - 2011
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.2010.01243.x
Subject(s) - dictyostelium , dictyostelium discoideum , multicellular organism , microbiology and biotechnology , biology , stat , signal transduction , cell signaling , cell fate determination , transcription factor , cell , genetics , gene , stat3
Signal transducers and activators of transcription (STAT) proteins are one of the important mediators of phosphotyrosine‐regulated signaling in metazoan cells. These proteins are components of JAK/STAT signal transduction pathways, which regulate immune responses, cell fate, proliferation, cell migration, and programmed cell death in multicellular organisms. The cellular slime mould, Dictyostelium discoideum , is the simplest multicellular organism using molecules homologous to STATs, Dd‐STATa–d. The Dd‐STATa null mutant displays delayed aggregation, no phototaxis and fails culmination. Here, the functions of Dictyostelium STATs during development and their associated signaling molecules are discussed.