Premium
Alternative splicing of SMADs in differentiation and tissue homeostasis
Author(s) -
Tao Shijie,
Sampath Karuna
Publication year - 2010
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.2009.01163.x
Subject(s) - alternative splicing , smad , rna splicing , gene isoform , splicing factor , microbiology and biotechnology , biology , effector , homeostasis , gene expression , regulation of gene expression , gene , signal transduction , genetics , rna
Tissue‐specific alternate splicing is an important means of regulating gene expression during development. The effector proteins for the transforming growth factor‐β signaling pathway, the SMADs, encode distinct isoforms generated via alternate splicing, which appear to have distinct tissue‐specific expression profiles and functions. Here, we discuss the roles of various SMAD isoforms, and the consequences of mis‐regulation of SMAD splicing in development and tissue homeostasis.