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Glycogen synthase kinase 3 in the world of cell migration
Author(s) -
Sun Tong,
Rodriguez Marbelys,
Kim Leung
Publication year - 2009
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.2009.01141.x
Subject(s) - gsk 3 , cell migration , microbiology and biotechnology , glycogen synthase , microtubule , cytoskeleton , cell , kinase , actin , gsk3b , actin cytoskeleton , biology , chemistry , phosphorylation , biochemistry
Glycogen synthase kinase 3 (GSK3) is one of the few master switch kinases that regulate many aspects of cell functions. Recent studies on cell polarization and migration have shown that GSK3 is also essential for proper regulation of these processes. GSK3 influences cell migration as one of the regulators of the spatiotemporally controlled dynamics of the actin cytoskeleton, microtubules, and cell‐to‐matrix adhesions. In this mini‐review, the effects of GSK3 on these three aspects of cell migration will be discussed.