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Continuous neurogenesis in the adult brain
Author(s) -
Imayoshi Itaru,
Sakamoto Masayuki,
Ohtsuka Toshiyuki,
Kageyama Ryoichiro
Publication year - 2009
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.2009.01094.x
Subject(s) - neurogenesis , dentate gyrus , olfactory bulb , neuroscience , hippocampal formation , neural stem cell , hippocampus , biology , biological neural network , olfactory memory , psychology , stem cell , central nervous system , microbiology and biotechnology
Neurogenesis occurs throughout adulthood in the mammalian brain by coordinated proliferation and differentiation of adult neural stem cells. Newborn neurons are incorporated into the functional networks of both the olfactory bulb and the hippocampal dentate gyrus, suggesting significant roles of adult neurogenesis in brain functions. In this review, we discuss the recent findings about the integration mode of new neurons into the existing neural circuits. We further address the potential significance of adult neurogenesis in higher brain functions such as olfactory and spatial memory.