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Neural activity‐dependent regulation of gene expression in developing and mature neurons
Author(s) -
Abe Kentaro
Publication year - 2008
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.2008.00999.x
Subject(s) - mechanism (biology) , neuroscience , biology , gene expression , transcription factor , regulation of gene expression , gene , function (biology) , synaptic plasticity , biological neural network , organism , signal transduction , neural development , microbiology and biotechnology , genetics , receptor , philosophy , epistemology
Neurons can change their gene expression patterns according to the inputs they have received. This activity‐dependent gene regulation mechanism plays an important role in the formation of neural circuits during development. Further, by regulating the synaptic plasticity, this mechanism may function as an essential one for each organism to adapt flexibly to its environment. This review summarizes our current knowledge about the activity‐dependent gene regulation mechanism in neurons, focusing on the transcription factors and signaling pathways involved in this mechanism.