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PI3K and ERK 1‐2 regulate early stages during head regeneration in hydra
Author(s) -
Manuel Gema C.,
Reynoso Rosalia,
Gee Lydia,
Salgado Luis M.,
Bode Hans R.
Publication year - 2006
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.2006.00847.x
Subject(s) - lernaean hydra , wnt signaling pathway , mapk/erk pathway , biology , microbiology and biotechnology , regeneration (biology) , signal transduction , pi3k/akt/mtor pathway , multicellular organism , genetics , cell
Different signaling systems coordinate and regulate the development of a multicellular organism. In hydra, the canonical Wnt pathway and the signal transduction pathways mediated by PKC and Src regulate early stages of head formation. In this paper, we present evidence for the participation of a third pathway, the PI3K‐PKB pathway, involved in this process. The data presented here are consistent with the participation of ERK 1‐2 as a point of convergence for the transduction pathways mediated by PKC, Src and PI3K for the regulation of the regeneration of the head in hydra. The specific developmental point regulated by them appears to be the commitment of tissue at the apical end of the regenerate to form the head organizer.