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Regulation of Wnt gene expression
Author(s) -
Tian Qi,
Jin Hong,
Cui Yanzhen,
Guo Changsheng,
Lu Xiang
Publication year - 2005
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.2005.00804.x
Subject(s) - wnt signaling pathway , morphogen , alternative splicing , rna splicing , biology , computational biology , gene expression , function (biology) , microbiology and biotechnology , regulation of gene expression , gene , transcriptional regulation , genetics , signal transduction , rna , messenger rna
Members of the Wnt gene family play important roles in the regulation of a number of basic developmental processes. Because Wnt is such a potent morphogen, its expression must be controlled tightly and precisely. While many review papers focused on Wnt signaling downstream of the receptor, this review addresses regulations of Wnt itself on several levels, including the transcriptional level, RNA splicing, the post‐transcriptional level, the translational level, and the post‐translational level. It is these multiple, precise and tight regulations that guarantee that Wnts function correctly both temporally and spatially.