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Sp1‐like transcription factors are regulators of embryonic development in vertebrates
Author(s) -
Zhao Chengtian,
Meng Anming
Publication year - 2005
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.2005.00797.x
Subject(s) - enhancer , biology , transcription factor , promoter , transactivation , vertebrate , repressor , embryonic stem cell , transcription (linguistics) , genetics , embryogenesis , gene , microbiology and biotechnology , gene expression , linguistics , philosophy
Sp1‐like family is an expanding transcription factor family. Members of this family bind to the GC‐box or GT‐box elements in the promoter/enhancers and regulate the expression of the target genes. Currently, this family consists of at least nine members, which may act as a transactivator or a repressor on target promoters. Sp1‐like transcription factors are expressed during development of vertebrate embryos in ubiquitous or tissue‐specific manners and play various roles in embryonic development. This review mainly summarises their expression patterns and functions during vertebrate embryogenesis.