Premium
Male Germ Cell‐Expressed Mouse Gene TAZ83 Encodes a Putative, Cysteine‐rich Transmembrane Protein ( cyritestin ) Sharing Homologies with Snake Toxins and Sperm‐Egg Fusion Proteins
Author(s) -
Heinlein Uwe A. O.,
Wallat Sabine,
Senftleben Annette,
Lemaire Lydia
Publication year - 1994
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1994.00049.x
Subject(s) - biology , complementary dna , gene , fusion protein , cysteine , microbiology and biotechnology , gene product , transmembrane protein , germ cell , peptide sequence , genetics , gene expression , biochemistry , recombinant dna , receptor , enzyme
Data obtained by cloning of a mouse cDNA ( TAZ83 ) are presented. Its corresponding gene is expressed in meiotic and haploid testicular germ cells. The gene encodes a putative, cysteine‐rich transmembrane protein with a deduced molecular weight of 90 kilodaltons and an isoelectric point of 5.4. Cysteine patterns within the predicted amino acid sequence of the TAZ83 gene product ( cyritestin , cysteine‐rich, testicular) are highly conserved when compared to various snake toxins of the disintegrin metalloproteinase type. The cysteine pattern conservation between cyritestin and a guinea pig sperm‐egg fusion protein suggests that TAZ83 codes for a mouse protein with comparable properties or function.