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Cooperative Activation of HoxD Homeobox Genes by Factors from the Polarizing Region and the Apical Ridge in Chick Limb Morphogenesis
Author(s) -
Koyama Eiki,
Noji Sumihare,
Nohno Tsutomu,
Myokai Fumio,
Ono Katsuhiko,
Nishijima Katsumi,
Kuroiwa Atsushi,
Ide Hiroyuki,
Taniguchi Shigehiko,
Saito Taiichi
Publication year - 1993
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1993.00189.x
Subject(s) - zone of polarizing activity , apical ectodermal ridge , homeobox , limb bud , limb development , biology , morphogenesis , anatomy , ridge , microbiology and biotechnology , gene , genetics , transcription factor , ectoderm , embryogenesis , paleontology
When a mouse zone of polarizing activity (ZPA) at the posterior margin of the limb bud was grafted into the anterior margin of the chick limb bud, the expressions of the chick homeobox genes HoxD12 and D13 were induced prior to the formation of chick extra digits. This induction was observed in a restricted domain close to both the grafted mouse ZPA and the chick apical ectodermal ridge (AER). When the posterior half of the AER was removed, the normal expression was diminished in the distaloposterior region. Thus, it is likely that at least two distinct factors, one from the ZPA and the other from the AER, act cooperatively to provide positional information to induce the sequential expression of the HoxD genes.