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Effects of Aphidicolin on Arylsulfatase Gene Expression in Sea Urchin Embryos
Author(s) -
Akasaka Koji,
Yamada Kazumi,
Sekine Koji,
Shimada Hiraku
Publication year - 1990
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1990.00299.x
Subject(s) - aphidicolin , biology , sea urchin , arylsulfatase , gene expression , embryo , gene , lytechinus variegatus , microbiology and biotechnology , dna replication , genetics , biochemistry , enzyme
Expression of the arylsulfatase (Ars) gene in sea urchin embryos begins just before hatching and ceases at the pluteus stage. Initiation of the Ars gene expression is inhibited by aphidicolin, which inhibits DNA synthesis without arresting the total RNA synthesis. Based on these finding it is supposed that DNA replication is a prerequisite for initiation of the Ars gene expression in developing sea urchin embryos.