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Cloning of a Gene Encoding Bombyxin, an Insulin‐Like Brain Secretory Peptide of the Silkmoth Bombyx mori with Prothoracicotropic Activity
Author(s) -
Iwami Masafumi,
Kawakami Atsushi,
Ishizaki Hironori,
Takahashi Susumu Y.,
Adachi Takashi,
Suzuki Yoshiaki,
Nagasawa Hiromichi,
Suzuki Akinori
Publication year - 1989
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1989.00031.x
Subject(s) - gene , bombyx mori , biology , intron , homology (biology) , genetics , insulin , bombyx , gene family , coding region , endocrinology , gene expression
A genomic DNA encoding bombyxin, a 5kD brain peptide of the silkmoth Bornbyx mori with prothoracicotropic hormone activity, has been isolated. The nucleotide sequence coding for bombyxin shows high homology with insulin‐gene family members and the overall organization of the preprobombyxin gene is the same as in preproinsulin genes, indicating that bombyxin shares a common ancestral molecule with insulin‐family peptides. The bombyxin gene has no intron contrasting to other members of insulin‐gene family.