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Changes during Development in the Activities and Intracellular Locations of Glycerol Kinase and Hexokinase in Rat Brain and Liver
Author(s) -
KANEKO MUNEKIYO,
ISHIBASHI SADAHIKO
Publication year - 1985
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1985.00745.x
Subject(s) - glycerol kinase , hexokinase , intracellular , glycerol , enzyme , biochemistry , kinase , biology , chemistry , endocrinology , glycolysis
The changes in activities and intracellular locations of glycerol kinase in rat brain and liver during development were compared. Glycerol kinase activity was consistently much higher in the liver than in the brain from just before the birth to the adult stage. Most of the activity was bound to mitochondria in the brain, but the intracellular distribution of the activity in the liver changed during development, the amount of activity bound to mitochondria being high just after birth and then decreasing gradually. These changes of glycerol kinase during development were compared with those of hexokinase, and the significance of the changes in the two enzymes is discussed in relation to dietary changes during development.