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Analysis of Differentiation of Hepatocytes and Bile Duct Cells in Developing Mouse Liver by Albumin Immunofluorescence
Author(s) -
SHIOJIRI NOBUYOSHI
Publication year - 1984
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1984.00555.x
Subject(s) - albumin , immunofluorescence , hepatocyte , bile duct , intrahepatic bile ducts , biology , embryo , serum albumin , indirect immunofluorescence , pathology , chemistry , medicine , microbiology and biotechnology , endocrinology , biochemistry , immunology , in vitro , antibody
Differentiation of endodermal cells in embryonic mouse liver was analyzed by study of their albumin immunofluorescence. Hepatocytes extending from the cranial diverticulum in 9.5‐day embryos do not contain albumin. In 10.5‐to 11.5‐day embryos, hepatocytes are still immature, but they all show albumin immunofluorescence. Most precursor cells of intrahepatic bile‐duct cells also give a positive reaction for albumin, like immature hepatocytes. The differentiation of intrahepatic bile‐duct cells from immature hepatocytes is suggested.