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Histogenesis of the Os Penis and Os Clitoridis in Rats
Author(s) -
MURAKAMI RYUTARO,
MIZUNO TAKEO
Publication year - 1984
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1984.00419.x
Subject(s) - penis , anatomy , fibrocartilage , histogenesis , hyaline cartilage , medicine , biology , pathology , immunohistochemistry , articular cartilage , osteoarthritis , alternative medicine
The development of the os penis in normal male rats and the os clitoridis in the females treated with testosterone were studied histologically and histochemically. Alcian blue‐positive materials, alkaline phosphatase activities and calcium deposit were detected. The os penis of the rats was composed of a proximal segment and a distal one. The proximal segment of the os penis was formed by the fusion of a membrane bone in its distal half and an ossifying hyaline cartilage in its proximal half. The distal segment of the os penis developed as a fibrocartilage bone. Two steps were demonstrated in the development of the os penis: the formation of the rudiments, and the differentiation of the proximal and distal segments. The treatment of newborn females with testosterone induced an os clitoridis homologous to the proximal segment of the os penis. The development of the os clitoridis was compared with that of the os penis.