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Reactivity of a Monoclonal Antibody Raised against Human Leukemic Cells to Embryonic and Adult Tissues of the Mouse and Teratocarcinomas
Author(s) -
SATO MASAHIRO,
OGATA SHUNICHIROH,
UEDA RYUZO,
NAMIKAWA REIKO,
TAKAHASHI TOSHITADA,
NAKAMURA TAKAO,
SATO EIICHI,
MURAMATSU TAKASHI
Publication year - 1983
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1983.00333.x
Subject(s) - biology , embryonic stem cell , antigen , ectoderm , histogenesis , epididymis , endoderm , embryo , endocrinology , andrology , immunology , embryogenesis , sperm , microbiology and biotechnology , immunohistochemistry , medicine , botany , biochemistry , gene
C‐9‐1, a monoclonal IgM antibody raised against human null cell acute lymphocytic leukemia cells reacted with restricted regions of embryonic and adult tissues of the mouse. The antigen positive sites in the embryos included embryonic ectoderm, visceral endoderm, trophoblastic cells invading the maternal decidua of 5∼7‐day embryos, primordial germ cells of 10∼12‐day embryos, epithelium of nasal chamber, the bronchus, Mullerian duct, epididymis and bladder of 12∼17‐day embryos. In the adult mice, C‐9‐1 antigen was detected in renal tubules, a part of stomach, bladder, endometrium and epididymal sperm. Embryonal carcinoma cells, but not endodermal cells of teratocarcinoma expressed the antigen. Thus, C‐9‐1 antigen showed distribution similar to SSEA‐1. However, C‐9‐1 antigen was not detected in preimplantation embryos, nor in oviduct, both of which are positive for SSEA‐1.