Premium
Germline‐specific Antigens Identified by Monoclonal Antibodies in the Nematode Caenorhabditis elegans 1
Author(s) -
YAMAGUCHI YASUNORI,
MURAKAMI KENJI,
FURUSAWA MITSURU,
MIWA JOHJI
Publication year - 1983
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1983.00121.x
Subject(s) - caenorhabditis elegans , germline , monoclonal antibody , biology , nematode , antigen , caenorhabditis , antibody , genetics , computational biology , microbiology and biotechnology , gene , ecology
Of 27 monoclonal antibodies identified to react, by indirect immunofluorescent antibody staining, with specific cells and tissues of the nematode Caenorhabditis elegans , we report here three monoclonal antibodies pertaining to the gonadal tissues. One antibody defines an antigen that is distributed over the entire embryo at earlier development and later becomes unique to the gonad, including mature oocytes. The antigens recognized by the other two are distributed asymmetrically in the posterior region of the fertilized egg's cytoplasm destined to become the germline precursor cell. Each antigen is successively segregated only to the germline precursor cells of the developing embryo and, postembryonically, is uniquely localized around the germline cell nuclei of the larvae and adults.