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Characterization of the Constituent Fatty Acids in the Phosphoglycerides of Chemically Induced Polycystic Disease and Gastric Tumor in Rat
Author(s) -
RYUZAKI MASASHI,
OHTA AKISHIGE,
OSHIMA MIEKO
Publication year - 1981
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1981.00507.x
Subject(s) - ethanolamine , fatty acid , choline , biology , medicine , stomach , biochemistry , endocrinology , chemistry
The positional distribution of fatty acids in choline‐ and ethanolamine phosphoglycerides from the livers of polycystic disease‐bearing rats and stomachs of gastric tumor‐bearing rats was analyzed and compared to that in normal rat liver and stomach. Polycystic disease and gastric tumors were induced with N‐Methyl‐N′‐Nitro‐N‐Nitrosoguanidine. There was no significant difference between diseased and normal organs with respect to the composition of fatty acids at the 1‐position, except that diseased livers exhibited an increase of approximately 22% in 16: 0 fatty acid and a decrease of approximately 12% in 18: 1 fatty acid. However, in diseased organs, there were marked quantitative changes in the positional distribution of fatty acids at the 2‐position, their composition exhibiting greater saturation. Furthermore, in diseased organs, there was an increase in 15: 0 fatty acid at the 2‐position of ethanolamine phosphoglycerides.