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The Degree of Differentiation in Early‐ and Late‐onset Forms of Platyfish‐swordtail Hybrid Melanomas: A Morphological and Physiological Study in Primary Culture
Author(s) -
WAKAMATSU YUKO,
OZATO KENJIRO
Publication year - 1981
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1981.00263.x
Subject(s) - xiphophorus , biology , melanosome , melanoma , fish <actinopterygii> , genetics , melanin , fishery
The early‐ and late‐onset forms of platyfish‐swordtail hybrid melanomas (fry and adult melanomas) and the macromelanophores of platyfish and melanotic hybrids were cultured and characterized according to their cellular morphology and physiology. The fry melanomas contained many large and broad cells. The pigmentation of these cells was somewhat less than that of the macromelanophores of platyfish. Most of the fry melanoma cells responded rapidly to 10 −6 M epinephrine, exhibiting reversible melanosome aggregation. The adult melanomas consisted of small, dendritic, and sparsely pigmented cells. The physiological response of these adult melanoma cells varied widely from tumor to tumor. These findings are discussed in relation to the differentiation of fish melanophores.