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INHIBITION OF THYROXINE‐INDUCED RESORPTION OF TADPOLE TAIL BY ADENOSINE 3′, 5′‐CYCLIC MONOPHOSPHATE
Author(s) -
YAMAMOTO KAZUTOSHI,
KIKUYAMA SAKAÉ,
YASUMASU IKUO
Publication year - 1979
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1979.00255.x
Subject(s) - medicine , endocrinology , prolactin , adenosine , phosphodiesterase , tadpole (physics) , caffeine , toad , cyclic nucleotide , in vivo , resorption , chemistry , phosphodiesterase inhibitor , nucleotide , biology , hormone , enzyme , biochemistry , physics , microbiology and biotechnology , particle physics , gene
Small segments of tail of Bufo bufo japonicus tadpoles were cultured in medium containing thyroxine (T 4 ) and dibutyryl cyclic AMP (dbcAMP). Like prolactin, the cyclic nucleotide blocked T 4 ‐induced shrinkage or tail pieces. Histological study of the segments after 4‐days culture revealed that dbcAMP suppressed degenerative changes induced by T 4 . The inhibitory effect of prolactin on T 4 ‐induced tail regression was promoted by caffeine, an inhibitor of adenosine 3′, 5′‐cyclic monophosphate (cyclic AMP)‐phosphodiesterase. The effect of prolactin on the level of cyclic AMP in the tail was also studied in vivo . Sixty min after prolactin injection, the cyclic AMP level was 2–3 times the control value. Possible involvement of cyclic AMP in the action of prolactin, which blocks tail resorption induced by T 4 , was discussed.