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GROWTH AND MITOTIC ACTIVITY OF LUNG COLONIES DERIVED FROM MOUSE TERATOCARCINOMAS
Author(s) -
ISHIKAWA TOMOICHI
Publication year - 1979
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1979.00169.x
Subject(s) - mitosis , biology , in vivo , lung , mitotic index , stage (stratigraphy) , microbiology and biotechnology , medicine , genetics , paleontology
This study dealt with the mitotic activity of lung colonies in the process of differentiation of mouse teratocarcinoma cells injected in vivo . The results showed that three stages were identifiable in respect to the mitotic activity: 1) a lag stage for a few days after injection, 2) a stage during which maximum mitotic activity is observed for several days following the first stage and 3) a third stage displaying a decrease in mitotic activity. There is a correspondence between these three steps in mitotic activity and differentiation in lung colonies previously identified by histological observations.