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EFFECTS OF BENZIMIDAZOLE ON CLEAVAGE OF THE SEA URCHIN EGG *
Author(s) -
KOJIMA MANABU KUNO
Publication year - 1972
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/j.1440-169x.1972.00085.x
Subject(s) - benzimidazole , sea urchin , parthenogenesis , cleavage (geology) , tonicity , biology , cleave , chemistry , andrology , anatomy , microbiology and biotechnology , biochemistry , embryo , enzyme , medicine , paleontology , organic chemistry , fracture (geology)
Unfertilized eggs of sea urchins were treated with benzimidazole. They were fertilized after being kept in normal sea water for a certain period. It was found that the first cleavage occurred much earlier than in the control. The eggs had a tendency to cleave directly into 3 or 4 cells. Benzimidazole induced some visible changes in unfertilized eggs, which was considered to be the result of an insufficient activation. Benzimidazole was found to have the same effect as hypertonic solution has in Loeb's “double treatment” method for artificial parthenogenesis. When eggs activated with butyric acid were treated with benzimidazole instead of hypertonic solution, they cleaved in a high percentage.