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Adipokines in inflammation, insulin resistance and cardiovascular disease
Author(s) -
Li ZhiYong,
Wang Pei,
Miao ChaoYu
Publication year - 2011
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2011.05602.x
Subject(s) - adipokine , insulin resistance , adipose tissue , inflammation , endocrine system , paracrine signalling , medicine , disease , obesity , endocrinology , bioinformatics , biology , hormone , receptor
Summary 1. Obesity is a major determinant of cardiovascular disease ( CVD ) . Studies in the past two decades have shown that adipose tissue is not merely an inert energy reserve of triglycerides, but also an active endocrine organ. 2. Adipose tissue can produce and secrete numerous bioactive peptides and/or proteins termed adipokines. These secretory factors are involved in the regulation of local and systemic inflammation and insulin sensitivity in a paracrine and/or endocrine manner. Inflammation and insulin resistance (IR) play critical roles in the obesity‐linked development of CVD, such as atherosclerosis, hypertension and restenosis. 3. In the present minireview, we summarize the relationship between inflammation and IR, as well as their contribution to the development of CVD during adipose tissue dysfunction. In particular, we focus on the effects of various adipokines in pathological processes, which may provide an insight into obesity‐linked CVD and facilitate the development of new therapeutic strategies.