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ABCC1 polymorphism Arg723Gln (2168G > A) is associated with lung cancer susceptibility in a Chinese population
Author(s) -
Yin JiYe,
Han LiFang,
Huang Qiong,
Xu XiaoJing,
Zhou HongHao,
Liu ZhaoQian
Publication year - 2011
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2011.05571.x
Subject(s) - lung cancer , odds ratio , lung cancer susceptibility , medicine , confidence interval , allele , gastroenterology , oncology , population , genotype , biology , genetics , single nucleotide polymorphism , gene , environmental health
Summary 1. In a previous in vitro study, we showed that the Arg723Gln (2168G > A) polymorphism significantly ABCC1‐induced multidrug resistance. The aim of the present study was to further investigate the association of this polymorphism with lung cancer susceptibility and chemotherapy response in a Chinese population. 2. A total of 77 lung cancer patients (54 men, 23 women) and 71 cancer‐free controls (49 men, 22 women) were enrolled in the study. Genomic DNA was extracted from peripheral blood and all samples were genotyped using polymerase chain reaction‐restriction fragment length polymorphism. 3. Individuals carrying the 723Gln (A) allele have a 3.4‐fold increased risk (adjusted odds ratio (OR) 3.42; 95% confidence interval (CI) 1.29–9.06; P = 0.013) of lung cancer compared with wild‐type individuals. Further stratified analysis indicated that older individuals (> 50 years) carrying the 723Gln (A) allele have the highest susceptibility to lung cancer (adjusted OR 4.10; 95% CI 1.25–13.48; P = 0.020). However, no substantial association was found between the Arg723Gln (2168G > A) polymorphism and chemotherapy response in Chinese lung cancer patients. 4. In conclusion, the Arg723Gln (2168G > A) polymorphism of ABCC1 appears to be a potential susceptibility marker for lung cancer in the Chinese population, especially in older people.