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Association of the aldosterone synthase gene −344T>C polymorphism with essential hypertension and glucose homeostasis: A case–control study in a Han Chinese population
Author(s) -
Li XiaoMu,
Ling Yan,
Lu DaRu,
Lu ZhiQiang,
Yi QianLu,
Liu Ying,
Chen HongYan,
Gao Xin
Publication year - 2011
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2011.05555.x
Subject(s) - aldosterone synthase , medicine , endocrinology , glucose homeostasis , homeostasis , aldosterone , blood pressure , essential hypertension , population , diabetes mellitus , insulin resistance , renin–angiotensin system , environmental health
Summary 1. Aldosterone is a hormone that affects both blood pressure and glucose homeostasis. We studied the association of the aldosterone synthase gene ( CYP11B2 ) polymorphism −344T>C with essential hypertension (EH) and glucose homeostasis in people in China. 2. We investigated the polymorphism −344T>C in CYP11B2 using a case–control study design (1059 cases and 1120 controls). Genotyping was carried out by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectroscopy using a MassARRAY platform. 3. The aldosterone synthase gene −344T>C polymorphism was found to be associated with EH (odds ratio 1.252; 95% confidence interval 1.067–1.468; P add = 0.006). The −344C variant was found to be significantly associated with increased systolic blood pressure ( P add = 0.003) and diastolic blood pressure ( P add = 0.024) in controls and increased plasma aldosterone levels ( P add = 0.0001) in EH cases. The −344C variant was also found to be significantly associated with increased fasting glucose ( P rec = 0.003) in controls. In the subgroup containing 893 EH cases without a history of diabetes or hypoglycaemia medications, the −344C variant was found to be associated with increased fasting and postprandial plasma glucose levels ( P add = 0.0001, P add = 0.001, respectively) and decreased pancreatic β‐cell function and insulin sensitivity ( P add = 0.030, P dom = 0.019, respectively) by homeostasis model assessments. 4. In this Han Chinese population, the −344T/C polymorphism of the CYP11B2 gene was found to be associated with EH and glucose homeostasis, both of which might be mediated by plasma aldosterone levels, insulin sensitivity and β‐cell function.