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High Susceptibility of Obese Hypertensive SHRSP.Z‐ Lepr fa /IzmDmcr Rats to Lipid Deposition in the Mesenteric Artery
Author(s) -
Kunimasa Kazuhiro,
Miura Chitose,
Mori Hideki,
Tsuchikura Satoru,
Ikeda Katsumi,
Gao Ming,
Yamori Yukio,
Mori Mari
Publication year - 2010
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2010.05440.x
Subject(s) - medicine , endocrinology , blood pressure , triglyceride , mesenteric arteries , obesity , cholesterol , spontaneously hypertensive rat , artery
Summary 1. Atherosclerosis is commonly observed in obesity. Obese atherosclerosis‐prone animals may be a promising tool for understanding the pathophysiology of obesity‐associated atherosclerosis. However, most rat strains are resistant to atherosclerosis. The aim of the present study was to assess the susceptibility of two obese hypertensive rat models, namely SHRSP.Z‐ Lepr fa /IzmDmcr rats (SHRSP‐fatty) and SHR.Cg‐ Lepr cp /NDmcr rats (SHR‐cp), to arterial lipid deposition, an initial stage of atherosclerosis, by comparing these strains with non‐obese stroke‐prone spontaneously hypertensive rats (SHRSP). 2. Eight‐week‐old male SHRSP, SHRSP‐fatty and SHR‐cp were fed a high‐fat and high‐cholesterol diet containing 20% palm oil, 5% cholesterol and 2% cholic acid for 5 weeks. Bodyweight, blood pressure and fasting serum levels of total cholesterol and triglycerides were measured in 12‐week‐old rats. Oil red O staining was used to visualize lipid deposition in the mesenteric artery. 3. The bodyweight of 12‐week‐old SHRSP‐fatty and SHR‐cp was higher than that of SHRSP ( P < 0.005). Systolic blood pressure in SHRSP and SHRSP‐fatty was higher than in SHR‐cp ( P < 0.005). Serum total cholesterol and triglyceride levels were elevated in SHRSP‐fatty ( P < 0.005) and SHR‐cp ( P < 0.05) compared with levels in SHRSP. Lipid deposition in the mesenteric artery was significantly greater in SHRSP‐fatty than in SHRSP (37.7 ± 4.9 vs 13.1 ± 2.8%, respectively; P < 0.005), but markedly reduced in SHR‐cp (1.8 ± 0.4%; P < 0.05). 4. The results of the present study indicate that SHRSP‐fatty are highly susceptible to arterial lipid deposition, whereas SHR‐cp are resistant. Thus, SHRSP‐fatty may be a useful obese rat model in which to investigate atherosclerotic processes.