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Secretory control: Evidence for agonist regulation of post‐fusion vesicle behaviour
Author(s) -
Soekmadji Carolina,
Thorn Peter
Publication year - 2010
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2009.05298.x
Subject(s) - vesicle , secretion , secretory vesicle , agonist , microbiology and biotechnology , secretory pathway , fusion , vesicle fusion , biology , exocytosis , chemistry , biochemistry , receptor , synaptic vesicle , membrane , endoplasmic reticulum , linguistics , philosophy , golgi apparatus
Summary 1. Here, we review recent work on vesicular secretion, with a focus on the control of post‐fusion events as a means of regulating secretory output. 2. In the classical model of secretion, each fused vesicle releases the entirety of its content in an all‐or‐none manner. In this way, the secretory output of a cell is controlled by regulating the numbers of fused vesicles. The realisation that post‐fusion events can control secretory output leads to a distinct model of partial release of vesicle content. 3. Recent work shows that post‐fusion events are under cellular control. Further, new data from our laboratory demonstrates agonist‐dependent regulation of fusion pore behaviour. 4. We conclude that post‐fusion events are not epiphenomena, but are likely an important mechanism of secretory control.