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ENDOCRINE REGULATION OF CALCIUM TRANSPORT IN EPITHELIA
Author(s) -
Khanal Ramesh C,
Nemere Ilka
Publication year - 2008
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2008.05053.x
Subject(s) - transcellular , calcium , paracellular transport , endocrine system , trpv6 , calcium metabolism , gastrointestinal tract , biology , kidney , microbiology and biotechnology , endocrinology , hormone , medicine , biochemistry , membrane , permeability (electromagnetism)
SUMMARY1 Calcium (re)absorption occurs in epithelia, including the intestine, kidney, mammary glands, placenta and gills (in the case of fish). 2 Calcium is transported across epithelia by two transport mechanisms, paracellular and transcellular, and the movement is regulated by a complex array of transport processes that are mediated by hormonal, developmental and physiological factors involving the gastrointestinal tract, bone, kidney and the parathyroids. 3 Clear understanding of the calcium transport pathways and their endocrine regulation is critical for minimizing various metabolic and health disorders at different physiological stages. Here, we first briefly review the calcium transport mechanisms before discussing in detail the endocrine factors that regulate calcium transport in the epithelia.