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EFFECT OF TEMPERATURE‐INDUCED REACTIVE OXYGEN SPECIES PRODUCTION ON EXCITATION–CONTRACTION COUPLING IN MAMMALIAN SKELETAL MUSCLE
Author(s) -
Van Der Poel Chris,
Edwards Joshua N,
Macdonald William A,
Stephenson D George
Publication year - 2008
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.2008.05050.x
Subject(s) - skeletal muscle , reactive oxygen species , contraction (grammar) , biophysics , oxygen , excitation–contraction coupling , mitochondrion , chemistry , mitochondrial ros , muscle contraction , biology , biochemistry , anatomy , endocrinology , organic chemistry
SUMMARY1 Here we review evidence obtained recently by us indicating that the poor longevity of isolated mammalian skeletal muscle preparations at temperatures in the normal physiological range is related to the increased production of reactive oxygen species (ROS) in the resting muscle. 2 Temperature‐induced ROS production increases markedly above 32°C in isolated, resting skeletal muscle and is associated with the gradual and irreversible functional deterioration of the muscle. 3 The majority of the temperature‐induced muscle ROS originates in the mitochondria and acts on various sites involved in excitation–contraction coupling.